Basic Information
VIS ID
TVIS10006992
Fusion event
HBV-TCAF2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26553052
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
Start
1593
End
1939
Orient
-
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
143440443/143743350 (Hg38)
End
143440443/143743350 (Hg38)
Orient
+
Location type
Intron
Target gene
TCAF2
miRNAs that regulate target gene
hsa-mir-15b-5p
Nearest miRNA
hsa-mir-10399/Upstream/360550; hsa-mir-153-2/Downstream/3634667;
Nearest TSS
ENST00000635602/Upstream/23667; ENST00000408955/Downstream/14346;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/122379, chr7-CpG: 72/Downstream/93338
Upstream sequence
GTAATAGAAGATTAAATAAAACAATGTACGTGAAATTGTCTTGTTGACTTAAAAAAAAAAAAAGCTGTAAAaatggaagaacataggctttgaaataaaa
Downstream sequence
catttcaaccttggtgaatctgacaattctgtgtcttggggttgctcttctcaaagagtatctttgtggtgttctctgtatttcctgaatttgaatgttg
Reference
Kawai-Kitahata, F., et al. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J Gastroenterol ,2016,51(5): 473-486.
Curate