Basic Information
VIS ID
TVIS10007016
Fusion event
HBV-chr17 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26553052
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
Start
1619
End
1809
Orient
-
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10365133/10461816 (Hg38)
End
10365133/10461816 (Hg38)
Orient
+
Location type
Intron
Target gene
MYH4 ; MYHAS
miRNAs that regulate target gene
hsa-mir-23a-3p
Nearest miRNA
hsa-mir-1253/Upstream/2274812; hsa-mir-10226/Downstream/1620083;
Nearest TSS
ENST00000595228/Upstream/39866; ENST00000579914/Downstream/7743;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/262693, chr17-CpG: 25/Downstream/176348
Upstream sequence
TATAATATTTCTGTGTCTTTTTTCTCTATCGAATTTTGATTACCTTTTTAGTTGCCCACATAGGCTTTGAAAAGGCTTATAAATGGGGGCAGGATTCAGA
Downstream sequence
GCAGGCAGAGGAAAATATGTTTATTTACCATTCTTACCTAAGACTCTTTCCCCAGATTATTGACTTCCACTTCCAGCTCACTAACTCTACCTATTTACAG
Reference
Kawai-Kitahata, F., et al. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J Gastroenterol ,2016,51(5): 473-486.
Curate