Basic Information
VIS ID
TVIS10007074
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26553052
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
Start
793
End
1034
Orient
-
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
126131994/124443425 (Hg38)
End
126131994/124443425 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/2026358; hsa-mir-202/Downstream/589358;
Nearest TSS
ENST00000439456/Upstream/24449; ENST00000487190/Downstream/6759;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/24132, chr10-CpG: 228/Downstream/3815
Nearby gene
NKX1-2(+359) ;
Upstream sequence
agcgattctcctgccccagcctcccgagtagctaggattacagacgcgcgcctccatgcccagctagttctctcatttttagtagagacggggttttacc
Downstream sequence
atgttggtcagtctggtctcgaactgttgacctcgtgatccacccacctcggcctcccaaagtgctgggattacaggcgtgacaacttttcttaagtcta
Reference
Kawai-Kitahata, F., et al. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J Gastroenterol ,2016,51(5): 473-486.
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