Basic Information
VIS ID
TVIS10007113
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
609
Orient
+
Integrated sequence
GGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCC| |ATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAG
Host Sequence
Chromosome
chr1
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
175199289/175230153 (Hg38)
End
175199289/175230153 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1G
Nearest miRNA
hsa-mir-101-1/Upstream/3085509; hsa-mir-1182/Downstream/738217;
Nearest TSS
ENST00000473358/Upstream/25304; ENST00000569593/Downstream/77065;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/37066, chr1-CpG: 42/Downstream/369087
Nearby gene
KIAA0040(-37060) ; TNR(+92646) ;
Upstream sequence
CCTTCAGCTGGGGTTCTATCATCTGTCAAGTAAATAGTTTTGATAATGAGAAAAGCAACCAGAAACGCAAATGAAAGGAGACAAAGAGTGTGAGTGAGCC
Downstream sequence
GGAGCAAGTTTAGATGAAACTTACAAATTCCTGCTGAGAGCCACATTGTCTCCTACGTAAACTCACACATTTATTTTTATTTATCCTGGCATAAAAAGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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