Basic Information
VIS ID
TVIS10007114
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2252
Orient
+
Integrated sequence
TAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGA| |GTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGA
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
178023494/178054359 (Hg38)
End
178023494/178054359 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/1024914; hsa-mir-1182/Downstream/623390;
Nearest TSS
ENST00000473358/Upstream/70056; ENST00000465723/Downstream/39213;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/16210, chr1-CpG: 67/Downstream/39759
Nearby gene
CRYZL2P(-16352) ; RASAL2-AS1(+37149) ;
Upstream sequence
ggcttcagtgagctgagattgtgctgctgcactccagcctgggcaacagagcgagactctgtctcaaaaataaataaataaaTAaataataataataata
Downstream sequence
ataataaAATTTTCAAGAGGAAGGAAGAAAAGTACTGGTGGGGATTTGAAGTGGTTTTTTTTTTTTTGTCATTGATGAGCACTGTCTATTGGGTTTCTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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