HSD11B1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007115
Fusion event
HBV-HSD11B1 integration
Validated
Yes
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
690
Orient
+
Integrated sequence
AAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCA| |TTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCT
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
209873705/209700360 (Hg38)
End
209873705/209700360 (Hg38)
Orient
+
Location type
Intronic
Target gene
HSD11B1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/76850; hsa-mir-1182/Downstream/2377253;
Nearest TSS
ENST00000473358/Upstream/14091; ENST00000367027/Downstream/4486;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/24277, chr1-CpG: 28/Downstream/47248
Upstream sequence
caggcatttccatacatcttctgaaatctaggcagaggttcccaaacttcaattcttgatttctgtgcaccatgtggaaggctcaacaccacgcggaagc
Downstream sequence
ttccaaggcttggggcttccaccctctgaagctaaagcctgagctctaggctagctcctttcaggctcctttcagctgggacacagggcaccaagtccct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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