Basic Information
VIS ID
TVIS10007116
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3188
Orient
+
Integrated sequence
TCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG| |
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
218960077/218786735 (Hg38)
End
218960077/218786735 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/6709050; hsa-mir-1182/Downstream/1331118;
Nearest TSS
ENST00000473358/Upstream/261895; ENST00000496776/Downstream/129449;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/439571, chr1-CpG: 46/Downstream/387032
Nearby gene
TGFB2(-342116) ; LYPLAL1-DT(+294240) ;
Upstream sequence
TATAGCTGTCTGATATAATTACTATGCATAATTAGGCAGTGTATAGAATACAATACAGAGGTCCTGGCAATTCTCTATAAAAGTGATTCTTTCCATTTTT
Downstream sequence
TTGTTGTTATTCTGTAGCCAACTCTGAGTTAAAACACAACAAAAGACAAATCTTGTAGACTATCTATTTTGCCCACTTAAACACACGTTTACATATACAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate