VISDB Viral Integration Site DataBase

VIS ID

TVIS10007117

Fusion event

HBV-DNAJC6 integration

Validated

Yes

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

282

Orient

-

Integrated sequence

AGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTA| |GGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGT

Chromosome

chr1

Cytoband

p31.3

Reference genome

Start

End

65760664/65294981 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-4260 ; hsa-mir-1227-5p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-6867-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p

Nearest miRNA

hsa-mir-101-1/Upstream/236473; hsa-mir-11399/Downstream/1333459;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/28815, chr1-CpG: 74/Downstream/14352

Upstream sequence

GCCAGAAAAAAAGTATAGGAGGTTTAGTTGAATATGTAAGGATTCTAAGTGGTAGCATGATGCTTATTATTTTTGCTACATTTATAATGTAAGCTTTTAT

Downstream sequence

TTAGGCATCTGAAGTTTTTCTTTTTATGTGTTATAGAGAAGTAGGGATGGAAGTGCTAATCCAATTATGTGAGGAAATCATAATAACTTCAGTGTATTGA