Basic Information
VIS ID
TVIS10007119
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2398
Orient
-
Integrated sequence
AGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC| |GAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42363345/41876862 (Hg38)
End
42363345/41876862 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6235610; hsa-mir-107/Downstream/1120701;
Nearest TSS
ENST00000439456/Upstream/3423681; ENST00000442306/Downstream/308477;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2933756, chr10-CpG: 184/Downstream/234171
Nearby gene
LOC441666(+463969) ;
Upstream sequence
attccattccattccactcaggttgattccgttcgattctatttcaatccattccattccattccattctagttgattccgttgcattccatgcggttcc
Downstream sequence
attccattccactccattccaatccattccactcgagttgattccattgcattccattccattccattccattccattccattccattccattccattcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate