Basic Information
VIS ID
TVIS10007123
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1905
Orient
-
Integrated sequence
CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG| |GACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCT
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
123932861/124062154 (Hg38)
End
123932861/124062154 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/680642; hsa-mir-3167/Downstream/2926304;
Nearest TSS
ENST00000527297/Upstream/20829; ENST00000533623/Downstream/53208;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/320317, chr11-CpG: 44/Downstream/560614
Nearby gene
OR10G7(-23153) ; VWA5A(+53250) ;
Nearest cancer related gene
VWA5A(TSG, +53250) ;
Upstream sequence
ttcgtgatgctctctcaccccaccaatttcatgtcttttaaagaaagttgagagaagaaaggaaagcaagtatatattcatagtttttgttataataaac
Downstream sequence
ttcttacttactatttctggttttctttctttctttctgtggattcaaattaccgtctagagtaattatcttagcccaatacagctctgcttccacccac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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