Basic Information
VIS ID
TVIS10007125
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1646
Orient
-
Integrated sequence
CTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCA| |AGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGG
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39317955/38924153 (Hg38)
End
39317955/38924153 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/13050074; hsa-let-7i/Downstream/3399547;
Nearest TSS
ENST00000382841/Upstream/16723; ENST00000405531/Downstream/168721;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/17275, chr12-CpG: 115/Downstream/220428
Nearby gene
CPNE8(-18535) ; KIF21A(+369075) ;
Upstream sequence
tgagaatatttttgtctttcattaaatgccatttggagtctagaattgtctggcagcaagctcagattccaattcaatggaactcttataggatctctag
Downstream sequence
tcaaagcgttcctccatggattctcaaacatgtggacaagaagatcccagagttgtataaaagcaaaTACTGtgactatgaaagagaatgcaccatttaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate