Basic Information
VIS ID
TVIS10007130
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1669
Orient
+
Integrated sequence
TGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTT| |GGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT
Host Sequence
Chromosome
chr12
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
74452176/74058396 (Hg38)
End
74452176/74058396 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/4473573; hsa-mir-1178/Downstream/5360861;
Nearest TSS
ENST00000382841/Upstream/19310; ENST00000519948/Downstream/225273;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1784625, chr12-CpG: 38/Downstream/479316
Nearby gene
TRHDE(-1392754) ; LOC100507377(+74780) ;
Upstream sequence
taaagcactcctcagcaaatgtaaaagaacagaaattataacaaactatctctcagaccgcagtgcaatcaaactagaactcaggattaagaaattcact
Downstream sequence
caaaactgctcaactacatggaaactgaacaacttgttcctgaatgactactgggtacataacgaaatgaaggcagaaataaagatgttctttgaaacca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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