Basic Information
VIS ID
TVIS10007135
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2417
Orient
+
Integrated sequence
TCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCG| |TCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTT
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30955269/30486063 (Hg38)
End
30955269/30486063 (Hg38)
Orient
+
Location type
Intronic
Target gene
G2E3-AS1 ; LOC112267868
Nearest miRNA
hsa-mir-208a/Upstream/2852785; hsa-mir-1185-1/Downstream/528583;
Nearest TSS
ENST00000550708/Upstream/11836; ENST00000555429/Downstream/17208;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/557849, chr14-CpG: 59/Downstream/72864
Nearby gene
PRKD1(-558370) ; G2E3(+73060) ;
Upstream sequence
CAAAATTATTCATTTGAAGGGTATCATAGAACAAAAAAAAAAAAACAGTACCAGTGGTCTGCATGGTTTTATTGACATGAGGAAGTATGCCAAAGAAATT
Downstream sequence
CAGATGGCAAAATTGCTTTATTAGAGATTCTTTGGCCAAGAGAAAATAAAAACTTGAAAAAATTAAAACTAGCTCTCTTCAAGATACCCCAAATCTTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate