Basic Information
VIS ID
TVIS10007137
Fusion event
HBV-DGLUCY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1531
Orient
+
Integrated sequence
TCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCAC| |CTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCC
Host Sequence
Chromosome
chr14
Cytoband
q32.11
Reference genome
GRCh37/hg19
Start
91660511/91194167 (Hg38)
End
91660511/91194167 (Hg38)
Orient
+
Location type
Intronic
Target gene
DGLUCY
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1260a/Upstream/13927877; hsa-mir-1185-1/Downstream/2754059;
Nearest TSS
ENST00000550708/Upstream/4380; ENST00000522816/Downstream/2226;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/132959, chr14-CpG: 87/Downstream/39570
Upstream sequence
TAGTATCCTATATCCTTGATCCAATTTTGAGGCAGTAAGAAagaaacatcctttacttagcactgaccgtgtgcacgacggccagccaggtagttagcac
Downstream sequence
acagcatgtcattgccctgtcgcggtagtcctgggaggtgggtgttaccccattttgtagaggaggtaaccaatggctgacatagcttgcccaaggtcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate