VISDB Viral Integration Site DataBase

VIS ID

TVIS10007138

Fusion event

HBV-PDPK1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

109

Orient

+

Integrated sequence

ACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCT| |CTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGG

Chromosome

chr16

Cytoband

p13.3

Reference genome

Start

End

2620047/2570046 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125a-5p ; hsa-mir-128-3p ; hsa-mir-10a-5p ; hsa-mir-24-3p ; hsa-mir-744-5p ; hsa-mir-423-5p ; hsa-mir-331-3p ; hsa-mir-185-5p ; hsa-mir-17-5p ; hsa-mir-3978 ; hsa-mir-6844 ; hsa-mir-421 ; hsa-mir-4261 ; hsa-mir-1245b-3p ; hsa-mir-4709-5p ; hsa-mir-5683 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-5010-3p ; hsa-mir-4452 ; hsa-mir-8068 ; hsa-mir-4725-5p ; hsa-mir-4680-3p ; hsa-mir-3121-5p ; hsa-mir-3140-5p ; hsa-mir-345-3p ; hsa-mir-4670-5p ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-4639-5p ; hsa-mir-346 ; hsa-mir-654-3p ; hsa-mir-6871-3p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-4477a ; hsa-mir-4680-5p ; hsa-mir-656-3p ; hsa-mir-1183 ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-618 ; hsa-mir-4668-5p ; hsa-mir-651-3p ; hsa-mir-329-5p ; hsa-mir-3942-3p ; hsa-mir-4284 ; hsa-mir-383-3p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-3191-5p ; hsa-mir-2117 ; hsa-mir-4527 ; hsa-mir-6503-5p ; hsa-mir-376c-3p ; hsa-mir-148a-5p ; hsa-mir-493-5p ; hsa-mir-129-5p

Nearest miRNA

hsa-mir-1225/Upstream/38041; hsa-mir-11401/Downstream/915335;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/4874, chr16-CpG: 24/Downstream/7087

Upstream sequence

GTGGTGTGGGCTTGGGAGATTGAGGAGGACCTCCTGGCAGAGAGGGACTTCTGCCTCCTCTCCTTGTACAGGAGCCTGTGGATGTATCTTGGTGAGGGCA

Downstream sequence

GCTGACTCAGAGTAAGCTTCCCACCTGGGCTGTCTCTGGCCTGTGCCCTCTATGCAAGAACCTTGGGGAGCTCGGGGTGTCCTTGGAGGTTCAGACTTGG