Basic Information
VIS ID
TVIS10007143
Fusion event
HBV-MIR924HG integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1774
Orient
-
Integrated sequence
CTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTA| |CTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTC
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
36898708/39318744 (Hg38)
End
36898708/39318744 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR924HG
Nearest miRNA
hsa-mir-1-2/Upstream/1661529; hsa-mir-122/Downstream/303379;
Nearest TSS
ENST00000575820/Upstream/4461; ENST00000636983/Downstream/21894;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1751079, chr18-CpG: 34/Downstream/522752
Upstream sequence
GAGAGGGAAAGCAGGCTGACAGCCCTGAAATGTGCCCAGGGTTTTGCAGCTGGAAAAGACAGATCAGAGTGGTGATTCAAGAAAATCCTGTCCCACATGG
Downstream sequence
GTTCTGATAAACATGCAAGCACTAAAACATTAAGCCACCTTTGTCAGCAGTCTTACATCCTCCTTTTTGTTTCCTTTCCTGCTAAGTTCTTTTATTAGCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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