Basic Information
VIS ID
TVIS10007146
Fusion event
HBV-LOC105373711 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1499
Orient
-
Integrated sequence
CTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTC| |CGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTC
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
158254075/157397563 (Hg38)
End
158254075/157397563 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105373711
Nearest miRNA
hsa-mir-128-1/Upstream/6029152; hsa-mir-10b/Downstream/1789272;
Nearest TSS
ENST00000437798/Upstream/69850; ENST00000604340/Downstream/41851;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/961066, chr2-CpG: 31/Downstream/199724
Nearby gene
ERMN(-69929) ; CYTIP(+17056) ;
Upstream sequence
caaaggacatgaactcatcattttttatggttgcatagtattccatggtgtatatgtgccacattttcttaatccagttttttgttgttgttgttgtttc
Downstream sequence
tcttctcttccattcttttcttttctttttttttTAttttattattattacactttaagttttagggtatatgtgcacaatgtgcaggttagttacatat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate