Basic Information
VIS ID
TVIS10007149
Fusion event
HBV-COPS9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2490
Orient
-
Integrated sequence
TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG| |GCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAG
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
241070377/240130960 (Hg38)
End
241070377/240130960 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA2J
Target gene
COPS9
Nearest miRNA
hsa-mir-10b/Upstream/187866; hsa-mir-149/Downstream/325041;
Nearest TSS
ENST00000437798/Upstream/83933; ENST00000426280/Downstream/3330;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/977, chr2-CpG: 72/Downstream/5026
Upstream sequence
AAACCTGATCCCGTTCAGAGATGAACAGAATCATCTAGGTCGTTAAGAACAGTCTTATCTTTCTGGTTAACCAGGTCCTAAATTCAAGGGATTTCCACGT
Downstream sequence
GTTCTTTAAAACCACCTGAAACTGTCCTGCGCAGGCTCACACTGCGGCTCTGTACCAAGGGCTTGGCCCCGCCTGCAGCCAGAGGGCATCTCACTGGATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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