Basic Information
VIS ID
TVIS10007157
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2398
Orient
-
Integrated sequence
AGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC| |GAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATT
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
10819576/10692879 (Hg38)
End
10819576/10692879 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10396a/Upstream/1705214; hsa-let-7c/Downstream/2713505;
Nearest TSS
ENST00000624081/Upstream/43044; ENST00000624445/Downstream/2323813;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/65155, chr21-CpG: 39/Downstream/2916736
Nearby gene
TEKT4P2(-850983) ; TPTE(+87167) ;
Upstream sequence
aatggaatggaatggaatggaatgcaatggaatggaatggaatggaatggaatgcaatggaatggaatggaatgcaatggaatggaatggaatggaatgc
Downstream sequence
aacggaatggaatggaatggaatggaatggaatggaatggaatggaatgcaatggaatggaatggaatggaatggaatggaatggaatggaatgcaatgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate