Basic Information
VIS ID
TVIS10007158
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2841
Orient
+
Integrated sequence
GACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGA| |TCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGA
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
30629217/30233228 (Hg38)
End
30629217/30233228 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22B
Nearest miRNA
hsa-mir-1286/Upstream/226115; hsa-let-7a-3/Downstream/498329;
Nearest TSS
ENST00000624155/Upstream/26119; ENST00000447565/Downstream/5966;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/152687, chr22-CpG: 19/Downstream/10512
Nearby gene
HORMAD2(-56155) ; LIF(+7219) ;
Upstream sequence
CCTCGGGGGTTCCCTGCTGCTGGGAAGCTGGACCTCCTGTGGGAGGAGTGGGGGAGGGGAGGCAAGCAGAGAATGCGGGAGGCTGAACTGAGTGGGGGGC
Downstream sequence
TCTGGAGGCTGGGGTTGGGGAGACAGAAAGACCCCCCACACATTTCTGTACTTTCTCTGCAGCCTCCAAGAGATCTGGGGTTCCCCTTACTCCATGTGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate