Basic Information
VIS ID
TVIS10007165
Fusion event
HBV-MDFIC2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
955
Orient
+
Integrated sequence
GATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAA| |ACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTG
Host Sequence
Chromosome
chr3
Cytoband
p13
Reference genome
GRCh37/hg19
Start
70249964/70200813 (Hg38)
End
70249964/70200813 (Hg38)
Orient
+
Location type
Intronic
Target gene
MDFIC2
Nearest miRNA
hsa-let-7g/Upstream/1151778; hsa-mir-12124/Downstream/1341157;
Nearest TSS
ENST00000440867/Upstream/200967; ENST00000641222/Downstream/82798;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/460756, chr3-CpG: 50/Downstream/864370
Nearby gene
MITF(-232476) ; FOXP1(+753901) ;
Upstream sequence
aggattccctatttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaatcatttc
Downstream sequence
tgactgtcctaaatcctaccaactgtaagatcgtagagcagagattcaaatctaagtctttctgaatccaaagcctgtggtctctatcccactgTTATAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate