Basic Information
VIS ID
TVIS10007169
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
652
Orient
-
Integrated sequence
ATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGG| |CCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTG
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68265697/67399979 (Hg38)
End
68265697/67399979 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1123051; hsa-mir-1243/Downstream/9173589;
Nearest TSS
ENST00000502981/Upstream/1396698; ENST00000265404/Downstream/21075;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1729023, chr4-CpG: 37/Downstream/145296
Nearby gene
EPHA5-AS1(-1706593) ; CENPC(+72292) ;
Upstream sequence
tccattccattccattccattccattccactcgggttgattacattccattccattccaatccattccattccattccattccattccattccattccat
Downstream sequence
ccaacgaaggacacaaagaggtccatatatccacttgctgaatttacaaggagagtgtctccaaactgctcaatcaaaagaaagtttaaactccgtgaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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