Basic Information
VIS ID
TVIS10007170
Fusion event
HBV-LOC101929210 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
616
Orient
-
Integrated sequence
TGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCAT| |CATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTC
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
End
95039765/94118614 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12113/Upstream/6818031; hsa-mir-1243/Downstream/4878773;
Nearby gene
ATOH1(-288623) ; SMARCAD1(+88994) ;
Upstream sequence
TTTATACAACGCATATCTCCACCCTTTCTTCAAAGTCTTTTCGCTTACACGGAAAGACttcttaaactgccatgcatcagggtcagggggaggtcttgtt
Downstream sequence
ccttgcttttgtatgctgtattatacagcttctcCATATGTACATAATTGGATAGTCATCACCTGTGGATTTTTTATATACTACTATCCAAATATTTTCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate