VISDB Viral Integration Site DataBase

VIS ID

TVIS10007173

Fusion event

HBV-UNC5C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2834

Orient

+

Integrated sequence

CAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGG| |AACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAA

Chromosome

chr4

Cytoband

q22.3

Reference genome

Start

End

96445166/95524015 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-4477b ; hsa-mir-488-3p ; hsa-mir-4496 ; hsa-mir-323a-3p ; hsa-mir-651-3p ; hsa-mir-6762-3p ; hsa-mir-93-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-500a-5p ; hsa-mir-222-5p ; hsa-mir-6806-5p ; hsa-mir-5088-3p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936

Nearest miRNA

hsa-mir-12113/Upstream/8223432; hsa-mir-1243/Downstream/3473372;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/765357, chr4-CpG: 20/Downstream/24290

Nearest cancer related gene

UNC5C(TSG, No orient, 0)

Upstream sequence

tgttgctcaggctggattgaactcctggccttaggtgatcctcctgcctcagcctgccaagtagctgggattacaggtacgagccaatgtgcccagcATA

Downstream sequence

CTTGGTCCTCTTCAGAGCACACAATCCTTTTTGCATAGTGATGATTCAATACACGTTTAAAAACATGTTGGAAAAGTTGAATTGAAATGGACTTTGAAAA