Basic Information
VIS ID
TVIS10007174
Fusion event
HBV-LOC102724404 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1929
Orient
-
Integrated sequence
CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT| |GGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAG
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
156876932/157449924 (Hg38)
End
156876932/157449924 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102724404
Nearest miRNA
hsa-mir-10397/Upstream/2620384; hsa-mir-103a-1/Downstream/3024478;
Nearest TSS
ENST00000502646/Upstream/64974; ENST00000521390/Downstream/10095;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/183185, chr5-CpG: 50/Downstream/10037
Nearby gene
CYFIP2(-54326) ; NIPAL4(+10095) ;
Upstream sequence
CCTctctcaaaagatatgtcctcatcaaaaccctaagacctgtgaatggtaacatatttgggaaaagtgcttttgcaggtgtaattaagttaataatctt
Downstream sequence
agcaaactgctcaaggtcacaaggctcaagaatggtggaggcaggatataaactcacgttatttgacttgagtttccttcttttacttgccactctaccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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