ZNF184 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007178
Fusion event
HBV-ZNF184 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
151
Orient
-
Integrated sequence
TATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGC| |TGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCT
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
27430137/27462358 (Hg38)
End
27430137/27462358 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF184
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-3143/Upstream/314670; hsa-mir-10398/Downstream/3121974;
Nearest TSS
ENST00000381078/Upstream/55394; ENST00000625477/Downstream/10323;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/73117, chr6-CpG: 43/Downstream/10476
Upstream sequence
aggattccctatttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaatcaattc
Downstream sequence
ggctaatttttttgtatttttagtagagacggggtttcactgtgttagccagaatgatctcgatctgctgacctcgtgatccacccgccttggcctccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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