KHDRBS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007179
Fusion event
HBV-KHDRBS2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
595
Orient
+
Integrated sequence
TCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATT| |GCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGT
Host Sequence
Chromosome
chr6
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
62403906/61694001 (Hg38)
End
62403906/61694001 (Hg38)
Orient
-
Location type
Intronic
Target gene
KHDRBS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10398/Upstream/4303789; hsa-mir-10524/Downstream/9682959;
Nearest TSS
ENST00000381078/Upstream/970853; ENST00000370659/Downstream/592226;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/3732451, chr6-CpG: 45/Downstream/591949
Upstream sequence
aggattccctatttaataaatggtgctgggaaaactggctagccatatgtagaaggctgaaactggatcccttccttacaccttatacaaaaatcaattc
Downstream sequence
TGATCCTGCCAGATATCATCAAATTTATCCTTTCCTTTGATCTCAGTGCATGTAATTCTGTGAAGCTCATGAGCATGATTTTCCTCAAATTGATGTAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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