Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007180
Fusion event
HBV-ESYT2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|Polymerase|
Start
1530
Orient
+
Integrated sequence
GTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCA| |CCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCC
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
End
158555009/158762318 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-21-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-3941 ; hsa-mir-4672 ; hsa-mir-4515 ; hsa-mir-1288-3p ; hsa-mir-4740-5p ; hsa-mir-3171 ; hsa-mir-298 ; hsa-mir-422a ; hsa-mir-378i ; hsa-mir-378h ; hsa-mir-378f ; hsa-mir-378e ; hsa-mir-378c ; hsa-mir-378d ; hsa-mir-378b ; hsa-mir-378a-3p ; hsa-mir-4330 ; hsa-mir-3158-5p ; hsa-mir-3654 ; hsa-mir-1245b-3p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-6757-3p ; hsa-mir-4418 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-8057 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-3664-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-10399/Upstream/170622;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/56998, chr7-CpG: 94/Downstream/41435
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
CACAGTGATTTTCCTAGAATGAGCACCTGATCTATCCTGTCTGGCTTAAAATCTCTCAATTGTTCCTAGTTGTCCTGGGAAGTCTCATGAACTCTCAAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.