Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007199
Fusion event
HBV-FHAD1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2298
Orient
+
Integrated sequence
ACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTAT| |AGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
Start
End
15677949/15351453 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12136/Upstream/2772430; hsa-mir-101-1/Downstream/1507496;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/103996, chr1-CpG: 127/Downstream/58101
Upstream sequence
taaaattaaaataaaaaaaTTTTTTTAAAAAGTCTCCTGCCTCCAAGTGGGCAGGGTTTGAATCAGGGCCCAGAGGCCGagtagttaaggcaagggcact
Downstream sequence
ggtgtctaagcctgcaccactccttcctggtgctgtgaccttggaacactgcttgtctttatactgcctcggttacagcctgcgtttcctttcttgtgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.