Basic Information
VIS ID
TVIS10007200
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
609
Orient
-
Integrated sequence
GGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCC| |ATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAG
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
187981102/188011971 (Hg38)
End
187981102/188011971 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/7573581; hsa-mir-1182/Downstream/4704357;
Nearest TSS
ENST00000473358/Upstream/370355; ENST00000569873/Downstream/206429;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1331022, chr1-CpG: 56/Downstream/4796531
Nearby gene
PLA2G4A(-1022989) ;
Upstream sequence
agggcaagggtcagtggatggaaaattactaagaggaaacatcaggagtaaggaagattcttgctaaagacaggccgggctgaccagatatcactttcga
Downstream sequence
aatggttgaagatgaaaaacctgatcagatattgaggatgatcagattatcaagagtggagaattcttgctaaactgacttagcatggttctttgctaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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