VISDB Viral Integration Site DataBase

VIS ID

TVIS10007207

Fusion event

HBV-CACNB2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1818

Orient

+

Integrated sequence

GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT

Chromosome

chr10

Cytoband

p12.32

Reference genome

Start

End

18604464/18315535 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-3653-5p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6865-3p ; hsa-mir-4260 ; hsa-mir-5572 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-4450 ; hsa-mir-2052 ; hsa-mir-186-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-208a-3p ; hsa-mir-208b-3p

Nearest miRNA

hsa-mir-1265/Upstream/470342; hsa-mir-107/Downstream/2236435;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/174244, chr10-CpG: 24/Downstream/336064

Upstream sequence

ggattgcttgagcccaggagtttgagatcagcctgggcagcaaaaagagaccttgtctctatttaaaaaaaaaaaaaaaaaaaaaaaaaaaaactttttt

Downstream sequence

tttttttaattagccagatgcagtggtgcctgcctgtggtcccagttgctctggagcctgaggtgggagggtaacttgagcacagaggttcaaggctgca