VISDB Viral Integration Site DataBase

VIS ID

TVIS10007220

Fusion event

HBV-DIP2C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

668

Orient

+

Integrated sequence

GCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTC| |CTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGT

Chromosome

chr10

Cytoband

p15.3

Reference genome

Start

End

656499/610559 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-545-3p ; hsa-mir-505-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-3529-3p ; hsa-mir-34a-3p ; hsa-mir-1281 ; hsa-mir-6881-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6852-3p ; hsa-mir-3909 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4677-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193

Nearest miRNA

hsa-mir-107/Downstream/31130;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/3971, chr10-CpG: 18/Downstream/12571

Upstream sequence

acaaggaaaagaaaatgtttaaagtgaaagacatcccaattacccagatttgatcaatatagggacgtatcaaggtatcacatgcaccctgaaaatatgt

Downstream sequence

acatatattatgtatcaacaaaaacaaaaaTAAACCAATGACAGAATCGTTTGCGAAGCAAGTGCAGGTAAGAACGGGGAGCCAgacatggtgtggctgt