Basic Information
VIS ID
TVIS10007221
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
637
Orient
-
Integrated sequence
GCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAAT| |TCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGT
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
66560725/64800968 (Hg38)
End
66560725/64800968 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/1427920; hsa-mir-107/Downstream/2602383;
Nearest TSS
ENST00000439456/Upstream/763688; ENST00000634479/Downstream/123550;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/629839, chr10-CpG: 44/Downstream/252909
Nearby gene
REEP3(-1175842) ; ANXA2P3(+24560) ;
Upstream sequence
cttctttctgcttaccataagcagtcagggacagttaagactccacaactttgcttagaaataacttcagccaagtagcttcgaataaacactagaacac
Downstream sequence
aaatacaattcagcaaagctctttgccactttgtaacaaagattttttttaatctattgtcaactaacatgctcatttccatttgatacctcatcagaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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