Basic Information
VIS ID
TVIS10007228
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
518
Orient
-
Integrated sequence
TGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATG| |CCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCA
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
61999640/61605859 (Hg38)
End
61999640/61605859 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1228/Upstream/3781167; hsa-let-7i/Downstream/654500;
Nearest TSS
ENST00000382841/Upstream/1512995; ENST00000546718/Downstream/221374;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2009133, chr12-CpG: 117/Downstream/585128
Nearby gene
SLC16A7(-1816005) ; TAFA2(+102389) ;
Upstream sequence
aggaagtgagatacctccagctttcttcttttcttcaagattgctttggctattaatgtcttttcttgttctatataattagaattttgtagggatttta
Downstream sequence
ttgaatctgtaaatcacattgggtggtacaaacattttaagaatattaattattccaatccatgaaaacaggataactttccacttatttgtgtcttctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate