Basic Information
VIS ID
TVIS10007239
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
40370513/39796376 (Hg38)
End
40370513/39796376 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-2276/Upstream/132241; hsa-mir-1267/Downstream/931440;
Nearest TSS
ENST00000623511/Upstream/108833; ENST00000455241/Downstream/385433;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/140332, chr13-CpG: 30/Downstream/375856
Nearby gene
COG6(-4711) ; LINC00332(+385433) ;
Upstream sequence
acacctgtaaacccagcattttgggaggcccaggcaggtgaatcacttgaggccaggagtttgagaccagcctgagcaatatagtgagatactatctata
Downstream sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaattttttttttttaattagccgggcgtggtggcacacacctgtagtcccagctactca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate