Basic Information
VIS ID
TVIS10007240
Fusion event
HBV-LOC100506071 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
31356637/30887431 (Hg38)
End
31356637/30887431 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC100506071
Nearest miRNA
hsa-mir-208a/Upstream/3254153; hsa-mir-1185-1/Downstream/127215;
Nearest TSS
ENST00000550708/Upstream/2243; ENST00000555417/Downstream/2242;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/12163, chr14-CpG: 113/Downstream/138157
Upstream sequence
tgcaatgaactgagatcgtgccattgtactccagcctgggcgacagagtgagactctgtctcaaaaagaaaaaaaaaaaaaaaaaaaaaCTTTTTCCCCC
Downstream sequence
CCGCTTAAGATAATAAAAACACACTCTGGTGTTATAAAAGGGTATAAGAAGGGTTTCTTTCTTCCTCACCCCAGCCTTAATATTACTTTTGGCACAGGCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate