Basic Information
VIS ID
TVIS10007245
Fusion event
HBV-DDX11L10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
403
Orient
+
Integrated sequence
GGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCT| |TCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAAC
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
60573/10573 (Hg38)
End
60573/10573 (Hg38)
Orient
-
Location type
upstream
Target gene
DDX11L10
Nearest miRNA
hsa-mir-11401/Downstream/6479;
Nearest TSS
ENST00000527434/Downstream/12337;
Nearest CpG islands
None/Target, None/Upstream, chr16-CpG: 29/Downstream/12270
Upstream sequence
cagtaccaccgaaatctgtgcaaaggagaacgcagctccgccctcgcggtgctctccgcgtctgtgctgaggagaacgcaactccgccgtcgcaaaggcg
Downstream sequence
cgcgccgcgccggcgcaggcgcagaggggcgcgccgcgccggcgcaggcgcagagacacatgctagcgcgtccaggggtggaggcgtggcgcaggcgcag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate