Basic Information
VIS ID
TVIS10007253
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2430
Orient
+
Integrated sequence
TCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCT| |CAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGG
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
27253791/29673826 (Hg38)
End
27253791/29673826 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/3082291; hsa-mir-122/Downstream/625084;
Nearest TSS
ENST00000575820/Upstream/145523; ENST00000583089/Downstream/1039449;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1495615, chr18-CpG: 128/Downstream/1367697
Nearby gene
CDH2(-1496346) ; MIR302F(+625085) ;
Upstream sequence
aaagatcatcaagattcaggagaaagttgaagcccaattcagtgaatccaaggattacaataaaactacataggagctgacagactcgatgaccacttta
Downstream sequence
tgaaagaaccaaacttatctaatagacctgaaaagcacactacaataatttcataatatgattgcaagtattaacagctgaatacaccaagttgaggaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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