VISDB Viral Integration Site DataBase

VIS ID

TVIS10007255

Fusion event

HBV-PPP5C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1942

Orient

-

Integrated sequence

ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA

Chromosome

chr19

Cytoband

q13.32

Reference genome

Start

End

46866565/46363308 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-99b-3p ; hsa-mir-615-3p

Nearest miRNA

hsa-mir-10395/Upstream/344259; hsa-let-7e/Downstream/345974;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/15887, chr19-CpG: 44/Downstream/48746

Upstream sequence

gaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgagatcccgccactgcactccagcctgggcgacagagcgagactccatctca

Downstream sequence

aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaacaattttaaactagttttatttgccaaaagatttactgatttactcaggtcatgtgaactt