Basic Information
VIS ID
TVIS10007258
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
614
Orient
+
Integrated sequence
CATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCC| |ATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTT
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
126513262/125755685 (Hg38)
End
126513262/125755685 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LINC01889 ; LOC105373598
Nearest miRNA
hsa-mir-1285-2/Upstream/12034317; hsa-mir-10b/Downstream/1667852;
Nearest TSS
ENST00000437798/Upstream/44716; ENST00000419223/Downstream/362300;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1730007, chr2-CpG: 51/Downstream/900435
Nearby gene
CNTNAP5(-840399) ; GYPC(+900249) ;
Upstream sequence
aaattaacgaccataACCAGTCATTCAGCGTGTACCTGGTATGTGCTTCCTGCAATTGTTCCAATCTGACCATGTAGCCTACAGCACATGCTATATGAGG
Downstream sequence
CCTTATGGATTGCAAGCTCTTGGACACTTACTTCCCATTCGATGTATAAAAACCCAACAGCCCAGACATAGGGAGGCTGCTGGCATCTGGCATCTCTCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate