Basic Information
VIS ID
TVIS10007259
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
183926806/183062078 (Hg38)
End
183926806/183062078 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/1756426; hsa-mir-1244-1/Downstream/1316897;
Nearest TSS
ENST00000437798/Upstream/23220; ENST00000342619/Downstream/16481;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/23525, chr2-CpG: 26/Downstream/198537
Nearby gene
NCKAP1(-23577) ; DUSP19(+16481) ;
Upstream sequence
CTAAACTTTAAGAAAATGCTGTCAACTTTAATAGGAAAAAAAGACTAAATTATTTGGAATTTATGGGAATGCAATCCAGTTGTGATGGTAAATAGTTTTA
Downstream sequence
TTTGttttttttttttttttttttttttttttttttttttttttttttgagatgaagtcccactcttttcacccgggctggagtgcaatggagcgatctc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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