Basic Information
VIS ID
TVIS10007263
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
218080352/217215629 (Hg38)
End
218080352/217215629 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101928278 ; LOC105373872
Nearest miRNA
hsa-mir-10b/Upstream/3457470; hsa-mir-1244-1/Downstream/684884;
Nearest TSS
ENST00000437798/Upstream/219723; ENST00000452813/Downstream/67110;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/405138, chr2-CpG: 23/Downstream/540927
Nearby gene
TNP1(-355570) ; DIRC3(+68394) ;
Upstream sequence
gctcactgcagcctgagcttctgggctcaggccatcctcccatttcagcctcgtgagttgctgagactacaggcatgtgccactatgcccagctgactta
Downstream sequence
aaattttttttttttttttttttttttttttttttttttttttttagagacgaggtctcattttgttgcccaggctggtctcaaactcctgcactcaagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate