Basic Information
VIS ID
TVIS10007265
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
35349236/35124170 (Hg38)
End
35349236/35124170 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/1705606; hsa-mir-10b/Downstream/347235;
Nearest TSS
ENST00000437798/Upstream/86954; ENST00000587255/Downstream/34914;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1396553, chr2-CpG: 191/Downstream/1231084
Nearby gene
MYADML(-1395952) ; CRIM1-DT(+1232656) ;
Upstream sequence
ATGATGTATGATGCATTACATTAAATAAGAAACTTCTTTGATGTCACATTTTACATTTTAAATGCACATTTTTTGATACCTAAAGCATTGTCTTTATCAG
Downstream sequence
TTGtttttttttttttttttttttttttttttttttttttcctgaggctgagtctctctctgttgcccaggctggagtgcagtggtgcaatctcggctca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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