Basic Information
VIS ID
TVIS10007269
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2332
Orient
+
Integrated sequence
GGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTC| |CGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCA
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
83878743/83651619 (Hg38)
End
83878743/83651619 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2L
Nearest miRNA
hsa-mir-1285-2/Upstream/3785036; hsa-mir-10b/Downstream/2131981;
Nearest TSS
ENST00000437798/Upstream/128805; ENST00000440495/Downstream/663489;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2184062, chr2-CpG: 27/Downstream/638971
Nearby gene
DHFRP3(-793850) ; FUNDC2P2(+639063) ;
Upstream sequence
TCATTCCCTTGGCCATCAAAATAGTTCTCATATAAAATTACAAGCATATATTCCAATAGGTGTTAGAAGGAATGGGCTTTCTATTAGAGAATAGTGGTTT
Downstream sequence
TTAAAAGATAGACTGAGAACTTCTCAGATAAAAGCTAATTAGCCTTTGAAACATGCAGAACTGGGAATGGAAAGACACCATAGACAGCTCTGAAAATCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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