Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene99340218077251896836089971748998008897443489745839005636
Basic Information
VIS ID
TVIS10007275
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1942
Orient
-
Integrated sequence
ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG| |AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
8986283/9005636 (Hg38)
End
8986283/9005636 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/1633944; hsa-mir-1-1/Downstream/1644000;
Nearest TSS
ENST00000382410/Upstream/43328; ENST00000416836/Downstream/63127;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/872691, chr20-CpG: 107/Downstream/62675
Nearby gene
PLCB1(-120736) ; PLCB4(+63418) ;
Upstream sequence
TGAACTTGGGGCTTCTAGAATCAGTTTCATATCCCTGGACGAAAGTTTTATCAGAAAATCAGGATTCCAAATACCAAAAGTAGAGAACAAAAAGTGATTT
Downstream sequence
GGaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaGGCCAACAGCTGCAGCTACTTACCTCCCATATCAAACGAAGTTATTTTAATTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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