Basic Information
VIS ID
TVIS10007280
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
900
Orient
+
Integrated sequence
GTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTT| |ATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAAT
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43261815/42865809 (Hg38)
End
43261815/42865809 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/942512; hsa-let-7a-3/Downstream/2335145;
Nearest TSS
ENST00000624155/Upstream/7703; ENST00000443063/Downstream/10398;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/8148, chr22-CpG: 26/Downstream/4175
Nearby gene
ARFGAP3(-8407) ; PACSIN2(+3957) ;
Upstream sequence
TTGCCCAGAAGCGGCCAGTGACTGTATGTAGTTCACATGCCCTGAGGCGGCTGCCTTGGTGATCCGAATGCTGTTGAGCTCAGGGTCTTTTAGGTCCTCG
Downstream sequence
TaccctaaccctaaccctaaccctaaccctaaGGCGCTCTGGGTTTCTGCAACCTTCGGGAGGTCTAGCACCTAGTATTCCTCTGGCGTCTGAGTTTTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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