Basic Information
VIS ID
TVIS10007281
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr3
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
120574945/120856098 (Hg38)
End
120574945/120856098 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/460369; hsa-mir-12124/Downstream/193542;
Nearest TSS
ENST00000440867/Upstream/19738; ENST00000495504/Downstream/51974;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/259455, chr3-CpG: 62/Downstream/51935
Nearby gene
GTF2E1(-73029) ; STXBP5L(+52105) ;
Upstream sequence
taggcatgggcaatgacttcattactgaaaccccaaaagcaacgacaacaaaagacaaaattgacaaatgggatctaattaaactaaagagcttctgaca
Downstream sequence
CCAGTGAACCAAGAGATTTAAGTAGCAGCTCCAGTGACAGAATATCTGGCTGGCTGTCTGGCTCCTGTGTGCTGGCGCCTCTCCATTCCCGCCCATCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate