Basic Information
VIS ID
TVIS10007289
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3131
Orient
+
Integrated sequence
AGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCT| |ACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
79824684/79775534 (Hg38)
End
79824684/79775534 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/267565; hsa-mir-12124/Downstream/5610176;
Nearest TSS
ENST00000440867/Upstream/7719; ENST00000473938/Downstream/989363;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/8784, chr3-CpG: 75/Downstream/1985630
Nearby gene
ROBO1(-7625) ; GBE1(+1714166) ;
Nearest cancer related gene
ROBO1(TSG, -7625) ;
Upstream sequence
tggtagtttcttttgctgtgcagaagctctttagtttaattcgatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
ttgggggcaaagacattaagtttttggttgatactggtgctgcacattcagtagtgaccaccccggccatccccttatccaagaaaaccattgatataat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate