Basic Information
VIS ID
TVIS10007292
Fusion event
HBV-LOC105374007 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
395
Orient
+
Integrated sequence
TGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTT| |TATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCC
Host Sequence
Chromosome
chr3
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
99194829/99475985 (Hg38)
End
99194829/99475985 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105374007
Nearest miRNA
hsa-let-7g/Upstream/3115946; hsa-mir-12124/Downstream/488329;
Nearest TSS
ENST00000440867/Upstream/494927; ENST00000471993/Downstream/24362;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/573933, chr3-CpG: 43/Downstream/341784
Nearby gene
DCBLD2(-574296) ; MIR548G(+78324) ;
Upstream sequence
AACGCTTCATCAAAAGCCATGACTATAATCCAAAGCTATTAGGTTTAAGCAACTTATTTGGAAATTATCACCTTCAAATAACATGTAGGGCAACCTCAGT
Downstream sequence
tttctgtttttttatttattttcttaggttttctttagttttgatgtgctttttactatgtagcttcttgagttgtaagtttaaataattgattttcagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate