Basic Information
VIS ID
TVIS10007294
Fusion event
HBV-LOC107986309 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
804
Orient
-
Integrated sequence
CGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTA| |CCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGG
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
GRCh37/hg19
Start
122434706/121513551 (Hg38)
End
122434706/121513551 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986309
Nearest miRNA
hsa-mir-12113/Upstream/6856697; hsa-mir-1305/Downstream/3993708;
Nearest TSS
ENST00000502981/Upstream/132492; ENST00000424958/Downstream/159007;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/132416, chr4-CpG: 100/Downstream/182756
Nearby gene
QRFPR(-132525) ; ANXA5(+154446) ;
Upstream sequence
GCTATGGTAGTTGAAGAATGAAAGTCTGAGCTTAAGGGAATGATCTGTCCCTGGAGGAAGTTGGGGGAAGGTAACAGCCAATAGGATGAAAGAGGGAGCC
Downstream sequence
tttcttacctccattatggagtagtagactgatttcatcttgatagtctgggtcagtcaccccagccaacactgtaactcccttcttagcctgttgactt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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